In the neuro-cognitive context of the 'Operant Conditioning Theory', which of the following statements is most appropriate and true regarding the neuro-biological nature of the 'Schedules of Reinforcement and Punishment' propounded by B.F. Skinner, the activation dynamics of reward expectancy, habit formation, and risk-benefit evaluation between the brain's 'Mesolimbic Dopamine Pathway' (VTA to Nucleus Accumbens), 'Orbitofrontal Cortex', and 'Striatum', the interrelationships of Edward Thorndike's 'Law of Effect', and their implications for modern primary inclusive classroom teaching, 'Neuro-Operant Optimized Pedagogy', and the promotion of positive reinforcement, self-regulated behavior, and holistic adaptive skills in students?