In the neuro-cognitive context of 'Methods of Learning and Maxims of Teaching', regarding the interrelationships between the maxims 'From Known to Unknown' and 'From Concrete to Abstract' propounded by Herbert Spencer and John Comenius, their neuro-biological nature, the activation dynamics of prior knowledge integration, schema remapping, and conceptual abstraction among the brain's 'Hippocampus', 'Parietal Lobe', and 'Dorsolateral Prefrontal Cortex' (DLPFC), and David Ausubel's 'Advance Organizer Theory', along with their implications for modern primary inclusive classroom teaching, cognitive-structured pedagogy, and the enhancement of cognitive efficiency, logical engagement, and holistic knowledge construction in students, which of the following statements is most appropriate and true?