In the neuro-cognitive context of 'Memory and Knowledge Construction', based on Eric Kandel's groundbreaking experiments on the marine slug 'Aplysia', the neuro-biological nature of 'Synaptic Plasticity and Long-Term Potentiation (LTP)' formulated through the molecular signaling cascades between the 'CA1 and CA3 regions of the hippocampus', 'N-methyl-D-aspartate (NMDA) receptors', and 'Calcium/calmodulin-dependent protein kinase II (CaMKII)', along with the activation dynamics of gene transcription and protein synthesis, and Donald Hebb's formulation of 'Hebbian Learning' ('Cells that fire together, wire together'), which of the following statements is most appropriate and true regarding their reciprocal interrelationships and implications for modern primary inclusive classroom teaching, active constructivist pedagogy, and the enhancement of long-term memory consolidation, neural network strengthening, and overall cognitive efficiency in students?